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Tirzepatide — SURMOUNT-1 (2022) and SURPASS-2 (2021) SURMOUNT-1 (Jastreboff et al., NEJM 2022): 2,539 non-diabetic adults with BMI ≥30, 72 weeks of tirzepatide 15 mg/week: Weight loss: −20.9% (vs −3.1% placebo) 91% of participants ≥5% loss, 56.7% ≥20% SURPASS-2 (Frías et al., NEJM 2021): 1,879 T2D patients head-to-head vs semaglutide 1 mg: HbA1c: −2.30% (tirzepatide 15 mg) vs −1.86% (semaglutide) Weight loss: −11.2 kg vs −5.7 kg Tirzepatide statistically outperforms semaglutide on both HbA1c and weight in a head-to-head trial — a rare outcome in incretin pharmacology
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